Publications of J. Deelen

Baghdadi, M.; Nespital, T.; Monzó, C.; Deelen, J.; Grönke, S.; Partridge, L.: Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension. Molecular Metabolism 81, 101902, p. 101902 (2024)

Šetinc, M.; Celinšćak, Ž.; Bočkor, L.; Petranović, M. Z.; Marković, A. S.; Salihović, M. P.; Deelen, J.; Škarić-Jurić, T.: The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age. Mechanisms of Ageing and Development, 111926, p. 111926 (2024)

Smulders, L.; Deelen, J.: Genetics of human longevity: From variants to genes to pathways. Journal of Internal Medicine (2023)

Popescu, I.; Deelen, J.; Illario, M.; Adams, J.: Challenges in anti‐aging medicine–trends in biomarker discovery and therapeutic interventions for a healthy lifespan. Journal of Cellular and Molecular Medicine (2023)

Astre, G.; Atlan, T.; Goshtchevsky, U.; Oron-Gottesman, A.; Smirnov, M.; Shapira, K.; Velan, A.; Deelen, J.; Levy, T.; Levanon, E. Y. et al.; Harel, I.: Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate. Developmental Cell (2023)

Treaster, S.; Deelen, J.; Daane, J. M.; Murabito, J.; Karasik, D.; Harris, M. P.: Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation. Science Advances 9 (2023)

Cohen, A. A.; Deelen, J.; Jones, O. R.: Editorial: Mechanisms and Pathways Contributing to the Diversity of Aging Across the Tree of Life. Front Cell Dev Biol 10, p. 854700 (2022)

Timmers, P. R. H. J.; Tiys, E. S.; Sakaue, S.; Akiyama, M.; Kiiskinen, T. T. J.; Zhou, W.; Hwang, S.-J.; Yao, C.; Kamatani, Y.; Zhou, W. et al.; Deelen, J.; Levy, D.; Ganna, A.; Kamatani, Y.; Okada, Y.; Joshi, P. K.; Wilson, J. F.; Tsepilov, Y. A.: Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging. Nature Aging 2, pp. 19 - 30 (2022)

Baghdadi, M.; Hinterding, H. M.; Partridge, L.; Deelen, J.: From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing. Briefings in Functional Genomics 1 (25), pp. 13 - 23 (2022)

Timmers, P. R. H. J.; Tiys, E. S.; Sakaue, S.; Akiyama, M.; Kiiskinen, T. T. J.; Zhou, W.; Hwang, S.-J.; Yao, C.; Kamatani, Y.; Zhou, W. et al.; Deelen, J.; Levy, D.; Ganna, A.; Kamatani, Y.; Okada, Y.; Joshi, P. K.; Wilson, J. F.; Tsepilov, Y. A.: Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging. Nature Aging 2 (1), pp. 19 - 30 (2022)

Deelen, J.: Targeting multimorbidity: Using healthspan and lifespan to identify biomarkers of ageing that pinpoint shared disease mechanisms. EBioMedicine 67, p. 103364 (2021)

Ahluwalia, T. S.; Prins, B. P.; Abdollahi, M.; Armstrong, N. J.; Aslibekyan, S.; Bain, L.; Jefferis, B.; Baumert, J.; Beekman, M.; Ben-Shlomo, Y. et al.; Bis, J. C.; Mitchell, B. D.; de Geus, E.; Delgado, G. E.; Marek, D.; Eriksson, J.; Kajantie, E.; Kanoni, S.; Kemp, J. P.; Lu, C.; Marioni, R. E.; McLachlan, S.; Milaneschi, Y.; Nolte, I. M.; Petrelis, A. M.; Porcu, E.; Sabater-Lleal, M.; Naderi, E.; Seppala, I.; Shah, T.; Singhal, G.; Standl, M.; Teumer, A.; Thalamuthu, A.; Thiering, E.; Trompet, S.; Ballantyne, C. M.; Benjamin, E. J.; Casas, J. P.; Toben, C.; Dedoussis, G.; Deelen, J.; Durda, P.; Engmann, J.; Feitosa, M. F.; Grallert, H.; Hammarstedt, A.; Harris, S. E.; Homuth, G.; Hottenga, J. J.; Jalkanen, S.; Jamshidi, Y.; Jawahar, M. C.; Jess, T.; Kivimaki, M.; Kleber, M. E.; Lahti, J.; Liu, Y.; Marques-Vidal, P.; Mellstrom, D.; Mooijaart, S. P.; Muller-Nurasyid, M.; Penninx, B.; Revez, J. A.; Rossing, P.; Raikkonen, K.; Sattar, N.; Scharnagl, H.; Sennblad, B.; Silveira, A.; Pourcain, B. S.; Timpson, N. J.; Trollor, J.; Group, C. I. W.; van Dongen, J.; Van Heemst, D.; Visvikis-Siest, S.; Vollenweider, P.; Volker, U.; Waldenberger, M.; Willemsen, G.; Zabaneh, D.; Morris, R. W.; Arnett, D. K.; Baune, B. T.; Boomsma, D. I.; Chang, Y. C.; Deary, I. J.; Deloukas, P.; Eriksson, J. G.; Evans, D. M.; Ferreira, M. A.; Gaunt, T.; Gudnason, V.; Hamsten, A.; Heinrich, J.; Hingorani, A.; Humphries, S. E.; Jukema, J. W.; Koeing, W.; Kumari, M.; Kutalik, Z.; Lawlor, D. A.; Lehtimaki, T.; Marz, W.; Mather, K.; Naitza, S.; Nauck, M.; Ohlsson, C.; Price, J. F.; Raitakari, O.; Rice, K.; Sachdev, P. S.; Slagboom, P. E.; Sorensen, T. I. A.; Spector, T.; Stacey, D.; Stathopoulou, M. G.; Tanaka, T.; Wannamethee, S. G.; Whincup, P.; Rotter, J. I.; Dehghan, A.; Boerwinkle, E.; Psaty, B. M.; Snieder, H.; Alizadeh, B. Z.: Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci. Hum Mol Genet 5 (30), pp. 393 - 409 (2021)

van den Akker, E. B.; Trompet, S.; Barkey Wolf, J. J. H.; Beekman, M.; Suchiman, H. E. D.; Deelen, J.; Asselbergs, F. W.; Boersma, E.; Cats, D.; Elders, P. M. et al.; Geleijnse, J. M.; Ikram, M. A.; Kloppenburg, M.; Mei, H.; Meulenbelt, I.; Mooijaart, S. P.; Nelissen, R.; Netea, M. G.; Penninx, B.; Slofstra, M.; Stehouwer, C. D. A.; Swertz, M. A.; Teunissen, C. E.; Terwindt, G. M.; t Hart, L. M.; van den Maagdenberg, A.; van der Harst, P.; van der Horst, I. C. C.; van der Kallen, C. J. H.; van Greevenbroek, M. M. J.; van Spil, W. E.; Wijmenga, C.; Zhernakova, A.; Zwinderman, A. H.; Sattar, N.; Jukema, J. W.; van Duijn, C. M.; Boomsma, D. I.; Reinders, M. J. T.; Slagboom, P. E.: Metabolic Age Based on the BBMRI-NL (1)H-NMR Metabolomics Repository as Biomarker of Age-related Disease. Circ Genom Precis Med 13 (5), pp. 541 - 547 (2020)

Pisanti, S.; Deelen, J.; Gallina, A. M.; Caputo, M.; Citro, M.; Abate, M.; Sacchi, N.; Vecchione, C.; Martinelli, R.: Correlation of the two most frequent HLA haplotypes in the Italian population to the differential regional incidence of Covid-19. J Transl Med 18 (1), p. 352 (2020)

Gutman, D.; Lidzbarsky, G.; Milman, S.; Gao, T.; Sin-Chan, P.; Gonzaga-Jauregui, C.; Regeneron Genetics, C.; Deelen, J.; Shuldiner, A. R.; Barzilai, N. et al.; Atzmon, G.: Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity. Aging Cell 19 (10), p. e13216 (2020)

Cohen, A. A.; Kennedy, B. K.; Anglas, U.; Bronikowski, A. M.; Deelen, J.; Dufour, F.; Ferbeyre, G.; Ferrucci, L.; Franceschi, C.; Frasca, D. et al.; Friguet, B.; Gaudreau, P.; Gladyshev, V. N.; Gonos, E. S.; Gorbunova, V.; Gut, P.; Ivanchenko, M.; Legault, V.; Lemaitre, J. F.; Liontis, T.; Liu, G. H.; Liu, M.; Maier, A. B.; Nobrega, O. T.; Rikkert, M.; Pawelec, G.; Rheault, S.; Senior, A. M.; Simm, A.; Soo, S.; Traa, A.; Ukraintseva, S.; Vanhaelen, Q.; Van Raamsdonk, J. M.; Witkowski, J. M.; Yashin, A. I.; Ziman, R.; Fulop, T.: Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mech Ageing Dev 191, p. 111316 (2020)

Timmers, P.; Wilson, J. F.; Joshi, P. K.; Deelen, J.: Multivariate genomic scan implicates novel loci and haem metabolism in human ageing. Nat Commun 11 (1), p. 3570 (2020)

Deelen, J.: Searching for the genetic key to a long and healthy life. Elife 9 (24), p. e57242 (2020)

Beekman, M.; Schutte, B. A. M.; Akker, E.; Noordam, R.; Dibbets-Schneider, P.; de Geus-Oei, L. F.; Deelen, J.; Rest, O. V.; Heemst, D. V.; Feskens, E. J. M. et al.; Slagboom, P. E.: Lifestyle-Intervention-Induced Reduction of Abdominal Fat Is Reflected by a Decreased Circulating Glycerol Level and an Increased HDL Diameter. Mol Nutr Food Res 64 (10), p. e1900818 (2020)

Klaric, L.; Tsepilov, Y. A.; Stanton, C. M.; Mangino, M.; Sikka, T. T.; Esko, T.; Pakhomov, E.; Salo, P.; Deelen, J.; McGurnaghan, S. J. et al.; Keser, T.; Vuckovic, F.; Ugrina, I.; Kristic, J.; Gudelj, I.; Stambuk, J.; Plomp, R.; Pucic-Bakovic, M.; Pavic, T.; Vilaj, M.; Trbojevic-Akmacic, I.; Drake, C.; Dobrinic, P.; Mlinarec, J.; Jelusic, B.; Richmond, A.; Timofeeva, M.; Grishchenko, A. K.; Dmitrieva, J.; Bermingham, M. L.; Sharapov, S. Z.; Farrington, S. M.; Theodoratou, E.; Uh, H. W.; Beekman, M.; Slagboom, E. P.; Louis, E.; Georges, M.; Wuhrer, M.; Colhoun, H. M.; Dunlop, M. G.; Perola, M.; Fischer, K.; Polasek, O.; Campbell, H.; Rudan, I.; Wilson, J. F.; Zoldos, V.; Vitart, V.; Spector, T.; Aulchenko, Y. S.; Lauc, G.; Hayward, C.: Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases. Sci Adv 6 (8), p. eaax0301 (2020)