Publications of L. Partridge

Fuentealba, M.; Donertas, H. M.; Williams, R.; Labbadia, J.; Thornton, J. M.; Partridge, L.: Using the drug-protein interactome to identify anti-ageing compounds for humans. PLoS Comput Biol 15 (1), p. e1006639 (2019)

Moens, T. G.; Niccoli, T.; Wilson, K. M.; Atilano, M. L.; Birsa, N.; Gittings, L. M.; Holbling, B. V.; Dyson, M. C.; Thoeng, A.; Neeves, J. et al.; Glaria, I.; Yu, L.; Bussmann, J.; Storkebaum, E.; Pardo, M.; Choudhary, J. S.; Fratta, P.; Partridge, L.; Isaacs, A. M.: C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A. Acta Neuropathol 137 (3), pp. 487 - 500 (2019)

Donertas, H. M.; Fuentealba, M.; Partridge, L.; Thornton, J. M.: Identifying Potential Ageing-Modulating Drugs In Silico. Trends Endocrinol Metab 30 (2), pp. 118 - 131 (2018)

Hahn, O.; Stubbs, T. M.; Reik, W.; Grönke, S.; Beyer, A.; Partridge, L.: Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity. PLoS Genet 14 (11), p. e1007766 (2018)

Kauppila, T. E. S.; Bratic, A.; Jensen, M. B.; Baggio, F.; Partridge, L.; Jasper, H.; Grönke, S.; Larsson, N.G.: Mutations of mitochondrial DNA are not major contributors to aging of fruit flies. Proc Natl Acad Sci U S A 115 (41), pp. E9620 - E9629 (2018)

Partridge, L.; Deelen, J.; Slagboom, P. E.: Facing up to the global challenges of ageing. Nature 561 (7721), pp. 45 - 56 (2018)

Flatt, T.; Partridge, L.: Horizons in the evolution of aging. BMC Biol 16 (1), p. 93 (2018)

Augustin, H.; McGourty, K.; Allen, M. J.; Adcott, J.; Wong, C. T.; Boucrot, E.; Partridge, L.: Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster. Neurobiol Aging 66, pp. 149 - 157 (2018)

Catterson, J. H.; Khericha, M.; Dyson, M. C.; Vincent, A. J.; Callard, R.; Haveron, S. M.; Rajasingam, A.; Ahmad, M.; Partridge, L.: Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension. Curr Biol 28 (11), pp. 1714 - 1724 e4 (2018)

Dönertas, H. M.; Fuentealba Valenzuela, M.; Partridge, L.; Thornton, J. M.: Gene Expression-Based Drug Repurposing to Target Ageing. Aging Cell, p. e12819 (2018)

Moens, T. G.; Mizielinska, S.; Niccoli, T.; Mitchell, J. S.; Thoeng, A.; Ridler, C. E.; Grönke, S.; Esser, J.; Heslegrave, A.; Zetterberg, H. et al.; Partridge, L.; Isaacs, A. M.: Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD. Acta Neuropathol 135 (3), pp. 445 - 457 (2018)

Simone, R.; Balendra, R.; Moens, T. G.; Preza, E.; Wilson, K. M.; Heslegrave, A.; Woodling, N. S.; Niccoli, T.; Gilbert-Jaramillo, J.; Abdelkarim, S. et al.; Clayton, E. L.; Clarke, M.; Konrad, M. T.; Nicoll, A. J.; Mitchell, J. S.; Calvo, A.; Chio, A.; Houlden, H.; Polke, J. M.; Ismail, M. A.; Stephens, C. E.; Vo, T.; Farahat, A. A.; Wilson, W. D.; Boykin, D. W.; Zetterberg, H.; Partridge, L.; Wray, S.; Parkinson, G.; Neidle, S.; Patani, R.; Fratta, P.; Isaacs, A. M.: G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo. EMBO Mol Med 10 (1), pp. 22 - 31 (2018)

Woodling, N. S.; Partridge, L.: Parkinson's Disease: Mitochondria Parked at the ER Hit the Snooze Button. Neuron 98 (6), pp. 1059 - 1061 (2018)

Augustin, H.; Adcott, J.; Elliott, C. J. H.; Partridge, L.: Complex Roles of Myoglianin in Regulating Adult Performance and Lifespan. Fly (Austin), p. 0 (2017)

Augustin, H.; McGourty, K.; Allen, M. J.; Madem, S. K.; Adcott, J.; Kerr, F.; Wong, C. T.; Vincent, A.; Godenschwege, T.; Boucrot, E. et al.; Partridge, L.: Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies. PLoS Biol 15 (9), p. e2001655 (2017)

Augustin, H.; McGourty, K.; Steinert, J. R.; Cocheme, H. M.; Adcott, J.; Cabecinha, M.; Vincent, A.; Halff, E. F.; Kittler, J. T.; Boucrot, E. et al.; Partridge, L.: Myostatin-like proteins regulate synaptic function and neuronal morphology. Development 144 (13), pp. 2445 - 2455 (2017)

Bolukbasi, E.; Khericha, M.; Regan, J. C.; Ivanov, D. K.; Adcott, J.; Dyson, M. C.; Nespital, T.; Thornton, J. M.; Alic, N.; Partridge, L.: Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity. Cell Rep 21 (3), pp. 641 - 653 (2017)

Brandt, T.; Mourier, A.; Tain, L. S.; Partridge, L.; Larsson, N.G.; Kuhlbrandt, W.: Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila. Elife 6 (2017)

Bustos, V.; Partridge, L.: Good Ol' Fat: Links between Lipid Signaling and Longevity. Trends Biochem Sci 42 (10), pp. 812 - 823 (2017)

Gorsky, M. K.; Burnouf, S.; Sofola-Adesakin, O.; Dols, J.; Augustin, H.; Weigelt, C. M.; Grönke, S.; Partridge, L.: Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity. Sci Rep 7 (1), p. 9984 (2017)