Publications of Sebastian Grönke

Lennicke, C.; Bjedov, I.; Grönke, S.; Menger, K. E.; James, A. M.; Castillo-Quan, J. I.; van Leeuwen, L. A. G.; Foley, A.; Buricova, M.; Adcott, J. et al.; Montoya, A.; Kramer, H. B.; Shliaha, P. V.; Logan, A.; Cabreiro, F.; Murphy, M. P.; Partridge, L.; Cochemé, H. M.: Enhancing autophagy by redox regulation extends lifespan in Drosophila. Nature Communications 16, 5379 (2025)

Gkioni, L.; Nespital, T.; Baghdadi, M.; Monzó, C.; Bali, J.; Nassr , T.; Cremer, A. L.; Beyer, A.; Deelen, J.; Backes, H. et al.; Grönke, S.; Partridge, L.: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan. Nature Aging (2025)

Zhang, P.; Catterson, J. H.; Grönke, S.; Partridge, L.: Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system. Nature Aging (2024)

Baghdadi, M.; Nespital, T.; Monzó, C.; Deelen, J.; Grönke, S.; Partridge, L.: Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension. Molecular Metabolism 81, 101902, p. 101902 (2024)

Morón-Oset, J.; Fischer, L. K. S.; Jauré, N.; Zhang, P.; Jahn, A. J.; Supèr, T.; Pahl, A.; Isaacs, A. M.; Grönke, S.; Partridge, L.: Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity. Acta Neuropathologica Communications 11, 140 (2023)

Debès, C.; Papadakis, A.; Grönke, S.; Karalay, O.; Tain, L. S.; Mizi, A.; Nakamura, S.; Hahn, O.; Weigelt, C. M.; Josipovic, N. et al.; Zirkel, A.; Brusius, I.; Sofiadis, K.; Lamprousi, M.; Lu, Y.-X.; Huang, W.; Esmaillie, R.; Kubacki, T.; Späth, M. R.; Schermer, B.; Benzing, T.; Müller, R.-U.; Antebi, A.; Partridge, L.; Papantonis, A.; Beyer, A.: Ageing-associated changes in transcriptional elongation influence longevity. Nature (2023)

Hahn, O.; Foltz, A. G.; Atkins, M.; Kedir, B.; Moran-Losada, P.; Guldner, I. H.; Munson, C.; Kern, F.; Pálovics, R.; Lu, N. et al.; Zhang, H.; Kaur, A.; Hull, J.; Huguenard, J. R.; Grönke, S.; Lehallier, B.; Partridge, L.; Keller, A.; Wyss-Coray, T.: Atlas of the aging mouse brain reveals white matter as vulnerable foci. Cell (2023)

Monzó, C.; Gkioni, L.; Beyer, A.; Valenzano, D. R.; Grönke, S.; Partridge, L.: Dietary restriction mitigates the age-associated decline in mouse B cell receptor repertoire diversity. Cell Reports 42, 112722, p. 112722 (2023)

Morón-Oset, J.; Fischer, L. K.; Carcolé, M.; Giblin, A.; Zhang, P.; Isaacs, A. M.; Grönke, S.; Partridge, L.: Toxicity ofC9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags. Life Science Alliance 6, p. e202201739 (2023)

Juricic, P.; Lu, Y.-X.; Leech, T.; Lisa, F.; Paulitz, J.; Lu, J.; Nespital, T.; Azami, S.; Regan, J. C.; Funk, E. et al.; Fröhlich, J.; Grönke, S.; Partridge, L.: Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Nature aging (2), pp. 824 - 836 (2022)

Srivastava, A.; Lu, J.; Gadalla, D. S.; Hendrich, O.; Grönke, S.; Partridge, L.: The Role of GCN2 Kinase in Mediating the Effects of Amino Acids on Longevity and Feeding Behaviour in Drosophila. Front Aging 3, p. 944466 (2022)

Annibal, A.; Tharyan, R. G.; Schonewolff, M. F.; Tam, H.; Latza, C.; Auler, M. M. K.; Grönke, S.; Partridge, L.; Annibal, A.: Regulation of the one carbon folate cycle as a shared metabolic signature of longevity. Nat Commun 12 (1), p. 3486 (2021)

Lu, Y.-X.; Regan, J. C.; Esser, J.; Drews, L. F.; Weinseis, T.; Stinn, J.; Hahn, O.; Miller, R. A.; Grönke, S.; Partridge, L.: A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing. Elife 10 (2021)

Tain, L.; Sehlke, R.; Meilenbrock, R. L.; Leech, T.; Paulitz, J.; Chokkalingam, M.; Nagaraj, N.; Grönke, S.; Fröhlich, J.; Atanassov, I. et al.; Mann, M.; Beyer, A.; Partridge, L.: Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila. Elife 10 (2021)

Atilano, M. L.; Grönke, S.; Niccoli, T.; Kempthorne, L.; Hahn, O.; Morón-Oset, J.; Hendrich, O.; Dyson, M.; Adams, M. L.; Hull, A. et al.; Salcher-Konrad, M. T.; Monaghan, A.; Bictash, M.; Glaria, I.; Isaacs, A. M.; Partridge, L.: Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila. Elife 10 (2021)

Kaeser, S. A.; Lehallier, B.; Thinggaard, M.; Häsler, L.M.; Apel, A.; Bergmann, C.; Berdnik, D.; Jeune, B.; Christensen, K.; Grönke, S. et al.; Partridge, L.; Wyss-Coray, T.; Mengel-From, J.; Jucker, M.: A neuronal blood marker is associated with mortality in old age. Nature Aging 1 (2), pp. 218 - 225 (2021)

Lu, J.; Temp, U.; Müller-Hartmann, A.; Esser, J.; Grönke, S.; Partridge, L.: Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids. Nature Aging 1 (1), pp. 60 - 72 (2021)

Weigelt, C. M.; Sehgal, R.; Tain, L.; Cheng, J.; Esser, J.; Pahl, A.; Dieterich, C.; Grönke, S.; Partridge, L.: An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila. Mol Cell 79 (2), pp. 268 - 279 e5 (2020)

Morón-Oset, J.; Supèr, T.; Esser, J.; Isaacs, A. M.; Grönke, S.; Partridge, L.: Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain. Acta Neuropathol Commun 7 (1), p. 209 (2019)

Hahn, O.; Drews, L. F.; Nguyen, A.; Tatsuta, T.; Gkioni, L.; Hendrich, O.; Zhang, Q.; Langer, T.; Pletcher, S.; Wakelam, M. J. O. et al.; Beyer, A.; Grönke, S.; Partridge, L.: A nutritional memory effect counteracts benefits of dietary restriction in old mice. Nat Metab 1 (11), pp. 1059 - 1073 (2019)