Department Langer

Mitochondrial Proteostasis

Mitochondria are dynamic metabolic organelles that participate in cellular signaling and adapt to varying physiological demands. The activity of mitochondria declines with age and a dysfunction of these organelles is associated with numerous age-associated diseases, raising the question: how do mitochondria influence cell fitness and ageing?The department seeks to define molecular mechanisms that preserve mitochondrial function with age and drive the dynamic adaptation of the mitochondrial proteome in a cell- and tissue-specific manner. Projects focus on the function of mitochondrial proteases that are emerging as central regulators and orchestrate complex interactions of mitochondria with their cellular environment.

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Personal Assistant

Michelle König



Third-party funding

  • 2021-2024 | German Research Council
    Collaborative Research Center 1218: Mitochondrial Regulation of Cellular Function.
  • 2020-2023 | German Research Council
    Collaborative Research Center 1403: Cell Death in Immunity, Inflammation and Disease.
  • 2020-2023 | German-Israel-Project MitoBalance
  • Postdoctoral fellowships Humboldt Foundation, EMBO, Japanese Science Foundation