Publications of L. Partridge

Kerr, F.; Sofola-Adesakin, O.; Ivanov, D. K.; Gatliff, J.; Gomez Perez-Nievas, B.; Bertrand, H. C.; Martinez, P.; Callard, R.; Snoeren, I.; Cocheme, H. M. et al.; Adcott, J.; Khericha, M.; Castillo-Quan, J. I.; Wells, G.; Noble, W.; Thornton, J.; Partridge, L.: Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease. PLoS Genet 13 (3), p. e1006593 (2017)

Mizielinska, S.; Ridler, C. E.; Balendra, R.; Thoeng, A.; Woodling, N. S.; Grasser, F. A.; Plagnol, V.; Lashley, T.; Partridge, L.; Isaacs, A. M.: Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration. Acta Neuropathol Commun 5 (1), p. 29 (2017)

Moens, T. G.; Partridge, L.; Isaacs, A. M.: Genetic models of C9orf72: what is toxic? Curr Opin Genet Dev 44, pp. 92 - 101 (2017)

Niccoli, T.; Partridge, L.; Isaacs, A. M.: Ageing as a risk factor for ALS/FTD. Hum Mol Genet 26 (R2), pp. R105 - R113 (2017)

Piper, M. D.; Soultoukis, G. A.; Blanc, E.; Mesaros, A.; Herbert, S. L.; Juricic, P.; He, X.; Atanassov, I.; Salmonowicz, H.; Yang, M. et al.; Simpson, S. J.; Ribeiro, C.; Partridge, L.: Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan. Cell Metab 25 (3), pp. 610 - 621 (2017)

Tain, L. S.; Sehlke, R.; Jain, C.; Chokkalingam, M.; Nagaraj, N.; Essers, P.; Rassner, M.; Grönke, S.; Froelich, J.; Dieterich, C. et al.; Mann, M.; Alic, N.; Beyer, A.; Partridge, L.: A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance. Mol Syst Biol 13 (9), p. 939 (2017)

Tiku, V.; Jain, C.; Raz, Y.; Nakamura, S.; Heestand, B.; Liu, W.; Spath, M.; Suchiman, H. E. D.; Muller, R. U.; Slagboom, P. E. et al.; Partridge, L.; Antebi, A.: Small nucleoli are a cellular hallmark of longevity. Nat Commun 8, p. 16083 (2017)

Zhao, Y.; Gilliat, A. F.; Ziehm, M.; Turmaine, M.; Wang, H.; Ezcurra, M.; Yang, C.; Phillips, G.; McBay, D.; Zhang, W. B. et al.; Partridge, L.; Pincus, Z.; Gems, D.: Two forms of death in ageing Caenorhabditis elegans. Nat Commun 8, p. 15458 (2017)

Ziehm, M.; Kaur, S.; Ivanov, D. K.; Ballester, P. J.; Marcus, D.; Partridge, L.; Thornton, J. M.: Drug repurposing for aging research using model organisms. Aging Cell 16 (5), pp. 1006 - 1015 (2017)

Soultoukis, G. A.; Partridge, L.: Dietary Protein, Metabolism, and Aging. Annu Rev Biochem 85, pp. 5 - 34 (2016)

Afschar, S.; Toivonen, J. M.; Hoffmann, J. M.; Tain, L. S.; Wieser, D.; Finlayson, A.; Driege, Y.; Alic, N.; Emran, S.; Stinn, J. et al.; Fröhlich, J.; Piper, M. D.; Partridge, L.: Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila. Proceedings of the National Academy of Sciences 113 (5), pp. 1321 - 1326 (2016)

Burnouf, S.; Grönke, S.; Augustin, H.; Dols, J.; Gorsky, M. K.; Werner, J. A.; Kerr, F.; Alic , N.; Martinez, P.; Partridge, L.: Deletion of endogenous Tau proteins is not detrimental in Drosophila. Scientific Reports 6, p. 23102 (2016)

Castillo-Quan, J. I.; Li, L.; Kinghorn, K. J.; Ivanov, D. K.; Tain, L. S.; Slack, C.; Kerr, F.; Nespital, T.; Thornton, J.; Hardy, J. et al.; Bjedov, I.; Partridge, L.: Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis. Cell Rep 15 (3), pp. 638 - 50 (2016)

Ding, X.; Bloch, W.; Iden, S.; Ruegg, M. A.; Hall, M. N.; Leptin, M.; Partridge, L.; Eming, S. A.: mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nat Commun 7, p. 13226 (2016)

Essers, P.; Tain, L. S.; Nespital, T.; Goncalves, J.; Fröhlich, J.; Partridge, L.: Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice. Sci Rep 6, p. 30290 (2016)

Gorsky, M. K.; Burnouf, S.; Dols, J.; Mandelkow, E.; Partridge, L.: Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. Scientific Reports 6, p. 22685 (2016)

Iyer, J.; Wang, Q.; Le, T.; Pizzo, L.; Grönke, S.; Ambegaokar, S. S.; Imai, Y.; Srivastava, A.; Troisi, B. L.; Mardon, G. et al.; Artero, R.; Jackson, G. R.; Isaacs, A. M.; Partridge, L.; Lu, B.; Kumar, J. P.; Girirajan, S.: Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster. G3 (Bethesda) 6 (5), pp. 1427 - 37 (2016)

Kakanj, P.; Moussian, B.; Grönke, S.; Bustos, V.; Eming, S. A.; Partridge, L.; Leptin, M.: Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing. Nat Commun 7, p. 12972 (2016)

Kinghorn, K. J.; Castillo-Quan, J. I.; Li, L.; Bhatia, K. P.; Abramov, A. Y.; Hardy, J.; Partridge, L.: Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications. Brain 139 (Pt 12), p. e68 (2016)

Kinghorn, K. J.; Grönke, S.; Castillo-Quan, J. I.; Woodling, N. S.; Li, L.; Sirka, E.; Gegg, M.; Mills, K.; Hardy, J.; Bjedov, I. et al.; Partridge, L.: A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin. J Neurosci 36 (46), pp. 11654 - 11670 (2016)