Max Planck Research Group Demetriades

Publications

Comprehensive Evaluation of Rapamycin’s Specificity as an mTOR Inhibitor

  • Artoni, F.
  • Grützmacher, N.
  • Demetriades, C.
(2022) bioRxiv, 2022.12.10.519872

Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor

  • Nicastro, R.
  • Brohée, L.
  • Alba, J.
  • Nüchel, J.
  • Figlia, G.
  • Kipschull, S.
  • Gollwitzer, P.
  • Romero-Pozuelo, J.
  • Fernandes, S. A.
  • Lamprakis, A.
  • Vanni, S.
  • Teleman, A. A.
  • De Virgilio, C.
  • Demetriades, C.
(2022) bioRxiv, 2022.11.06.515351

Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity

  • Huang, W.
  • Kew, C.
  • Fernandes, S.
  • Löhrke, A.
  • Han, L.
  • Demetriades, C.
  • Antebi, A.
(2022) Nature Aging, 2, 9, 796-808

A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids

  • Gollwitzer, P.
  • Grützmacher, N.
  • Wilhelm, S.
  • Kümmel, D.
  • Demetriades, C.
(2022) Nat Cell Biol

GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome

  • Demetriades, C.
  • Nuuchel, J.
  • Plomann, M.
(2021) Cell Stress, 5, 11, 173-175

The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging

  • Fernandes, S. A.
  • Demetriades, C.
(2021) Frontiers in Aging, 2

An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

  • Nuechel, J.
  • Tauber, M.
  • Nolte, J. L.
  • Morgelin, M.
  • Turk, C.
  • Eckes, B.
  • Demetriades, C.
  • Plomann, M.
(2021) Mol Cell, 81, 16, 3275-3293

TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation

  • Fitzian, K.
  • Bruckner, A.
  • Brohee, L.
  • Zech, R.
  • Antoni, C.
  • Kiontke, S.
  • Gasper, R.
  • Linard Matos, A. L.
  • Beel, S.
  • Wilhelm, S.
  • Gerke, V.
  • Ungermann, C.
  • Nellist, M.
  • Raunser, S.
  • Demetriades, C.
  • Oeckinghaus, A.
  • Kummel, D.
(2021) Mol Cell, 81, 13, 2705-2721

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

  • Prentzell, M. T.
  • Rehbein, U.
  • Cadena Sandoval, M.
  • De Meulemeester, A. S.
  • Baumeister, R.
  • Brohee, L.
  • Berdel, B.
  • Bockwoldt, M.
  • Carroll, B.
  • Chowdhury, S. R.
  • von Deimling, A.
  • Demetriades, C.
  • Figlia, G.
  • Genomics England Research, Consortium
  • de Araujo, M. E. G.
  • Heberle, A. M.
  • Heiland, I.
  • Holzwarth, B.
  • Huber, L. A.
  • Jaworski, J.
  • Kedra, M.
  • Kern, K.
  • Kopach, A.
  • Korolchuk, V. I.
  • van 't Land-Kuper, I.
  • Macias, M.
  • Nellist, M.
  • Palm, W.
  • Pusch, S.
  • Ramos Pittol, J. M.
  • Reil, M.
  • Reintjes, A.
  • Reuter, F.
  • Sampson, J. R.
  • Scheldeman, C.
  • Siekierska, A.
  • Stefan, E.
  • Teleman, A. A.
  • Thomas, L. E.
  • Torres-Quesada, O.
  • Trump, S.
  • West, H. D.
  • de Witte, P.
  • Woltering, S.
  • Yordanov, T. E.
  • Zmorzynska, J.
  • Opitz, C. A.
  • Thedieck, K.
(2021) Cell, 184, 3, 655-674 e27

CycD/Cdk4 and Discontinuities in Dpp Signaling Activate TORC1 in the Drosophila Wing Disc

  • Romero-Pozuelo, J.
  • Demetriades, C.
  • Schroeder, P.
  • Teleman, A. A.
(2017) Dev Cell, 42, 4, 376-387 e5

eIF4A inactivates TORC1 in response to amino acid starvation

  • Tsokanos, F. F.*
  • Albert, M. A.*
  • Demetriades, C.*
  • Spirohn, K.
  • Boutros, M.
  • Teleman, A. A.
(2016) EMBO J, 35, 10, 1058-76

Lysosomal recruitment of TSC2 is a universal response to cellular stress

  • Demetriades, C.**
  • Plescher, M.
  • Teleman, A. A.**
(2016) Nat Commun, 7, 10662

TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1

  • Plescher, M.
  • Teleman, A. A.**
  • Demetriades, C.**
(2015) Sci Rep, 5, 13828

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2

  • Demetriades, C.**
  • Doumpas, N.
  • Teleman, A. A.**
(2014) Cell, 156, 4, 786-99

Genomic analysis reveals a novel nuclear factor-kappaB (NF-kappaB)-binding site in Alu-repetitive elements

  • Antonaki, A.*
  • Demetriades, C.*
  • Polyzos, A.*
  • Banos, A.*
  • Vatsellas, G.
  • Lavigne, M. D.
  • Apostolou, E.
  • Mantouvalou, E.
  • Papadopoulou, D.
  • Mosialos, G.
  • Thanos, D.
(2011) J Biol Chem, 286, 44, 38768-82

The LMP1 promoter can be transactivated directly by NF-kappaB

  • Demetriades, C.
  • Mosialos, G.
(2009) J Virol, 83, 10, 5269-77

Functional characterization of hepatocyte nuclear factor-4 alpha dimerization interface mutants

  • Aggelidou, E.*
  • Iordanidou, P.*
  • Demetriades, C.
  • Piltsi, O.
  • Hadzopoulou-Cladaras, M.
(2006) FEBS J, 273, 9, 1948-58

Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4alpha

  • Iordanidou, P.*
  • Aggelidou, E.*
  • Demetriades, C.
  • Hadzopoulou-Cladaras, M.
(2005) J Biol Chem, 280, 23, 21810-9

*equal contribution; **corresponding author