Publications of J. B. Stewart

Rackham, O.; Busch, J. D.; Matic, S.; Siira, S. J.; Kuznetsova, I.; Atanassov, I.; Ermer, J. A.; Shearwood, A. M.; Richman, T. R.; Stewart, J. B. et al.; Mourier, A.; Milenkovic, D.; Larsson, N.G.; Filipovska, A.: Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly. Cell Rep 16 (7), pp. 1874 - 90 (2016)

Jokinen, R.; Marttinen, P.; Stewart, J. B.; Neil Dear, T.; Battersby, B. J.: Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division. Hum Mol Genet 25 (4), pp. 706 - 14 (2016)

Kauppila, J. H. K.; Baines, H. L.; Bratic, A.; Simard, M.-L.; Freyer, C.; Mourier, A.; Stamp, C.; Filograna, R.; Larsson, N.G.; Greaves, L. C. et al.; Stewart, J. B.: A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease. Cell reports 16 (11), pp. 2980 - 2990 (2016)

Rackham, O.; Busch, J. D.; Matic, S.; Siira, S. .; Kuznetsova, I.; Atanassov, I.; Ermer, J. .; Shearwood, A.-M. J.; Richman, T. .; Stewart, J. B. et al.; Mourier, A.; Milenkovic, D.; Larsson, N.G.; Filipovska, A.: Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly. Cell Reports 16 (7), pp. 1874 - 1890 (2016)

Bratic, A.; Kauppila, T. E. S.; Macao , B.; Grönke, S.; Siibak, T.; Stewart, J. B.; Baggio, F.; Dols, J.; Partridge, L.; Falkenberg, M. et al.; Wredenberg, A.; Larsson, N.G.: Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies. Nat Commun 6, p. 8808 (2015)

Kauppila, J. H. K.; Stewart, J. B.: Mitochondrial DNA: Radically free of free-radical driven mutations. Biochim Biophys Acta 1847 (11), pp. 1354 - 61 (2015)

Macao, B.; Uhler, J. P.; Siibak, T.; Zhu, X.; Shi, Y.; Sheng, W.; Olsson, M.; Stewart, J. B.; Gustafsson, C. M.; Falkenberg, M.: The exonuclease activity of DNA polymerase gamma is required for ligation during mitochondrial DNA replication. Nat Commun 6, p. 7303 (2015)

Stewart, J. B.; Alaei-Mahabadi, B.; Sabarinathan, R.; Samuelsson, T.; Gorodkin, J.; Gustafsson, C. M.; Larsson , E.: Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers. PLoS Genet 11 (6), p. e1005333 (2015)

Stewart, J.; Chinnery, P. F.: The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease. Nat Rev Genet 16 (9), pp. 530 - 42 (2015)

Stewart, J.; Larsson, N.G.: Keeping mtDNA in shape between generations. PLoS Genet 10 (10), p. e1004670 (2014)

Baines, H. L.; Stewart, J. B.; Stamp, C.; Zupanic, A.; Kirkwood, T. B. L.; Larsson, N.G.; Turnbull, D. M.; Greaves, L. C.: Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans. Mech. Ageing Dev. 139, pp. 22 - 30 (2014)

Chinnery, P. F.; Craven, L.; Mitalipov, S.; Stewart, J. B.; Herbert, M.; Turnbull, D. M.: The challenges of mitochondrial replacement. PLoS Genet 10 (4), p. e1004315 (2014)

Deceglie, S.; Lionetti, C.; Stewart, J. B.; Habermann, B.H.; Roberti, M.; Cantatore, P.; Loguercio Polosa, P.: Characterization of the sea urchin mitochondrial transcription factor A reveals unusual features. Mitochondrion 14 (1), pp. 34 - 41 (2014)

Wang, W.; Scheffler, K.; Esbensen, Y.; Strand, J. M.; Stewart, J.; Bjoras, M.; Eide, L.: Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age. PLoS ONE 9 (5), p. e96940 (2014)

Hagstrom, E.; Freyer, C.; Battersby, B. J.; Stewart, J. B.; Larsson, N.G.: No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline. Nucleic Acids Res 42 (2), pp. 1111 - 6 (2013)

Ross, J. M.; Stewart, J. B.; Hagstrom, E.; Brene, S.; Mourier, A.; Coppotelli, G.; Freyer, C.; Lagouge, M.; Hoffer, B. J.; Olson, L. et al.; Larsson, N.G.: Germline mitochondrial DNA mutations aggravate ageing and can impair brain development. Nature 501 (7467), pp. 412 - 5 (2013)

Terzioglu, M.; Ruzzenente, B.; Harmel, J.; Mourier, A.; Jemt, E.; Lopez, M. D.; Kukat, C.; Stewart, J.; Wibom, R.; Meharg, C. et al.; Habermann, B.; Falkenberg, M.; Gustafsson, C. M.; Park, C. B.; Larsson, N.G.: MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation. Cell Metab 17 (4), pp. 618 - 26 (2013)

Wanrooij, S.; Miralles Fuste, J.; Stewart, J.; Wanrooij, P. H.; Samuelsson, T.; Larsson, N. G.; Gustafsson, C. M.; Falkenberg, M.: In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication. EMBO Rep 13 (12), pp. 1130 - 7 (2012)

Damas, J.; Carneiro, J.; Goncalves, J.; Stewart, J. B.; Samuels, D. C.; Amorim, A.; Pereira, F.: Mitochondrial DNA deletions are associated with non-B DNA conformations. Nucleic Acids Res 40 (16), pp. 7606 - 21 (2012)

Freyer, C.; Cree , L. M.; Mourier, A.; Stewart, J. B.; Koolmeister, C.; Milenkovic, D.; Wai, T.; Floros, V. I.; Hagstrom, E.; Chatzidaki, E. E. et al.; Wiesner, R. J.; Samuels, D. C.; Larsson, N.G.; Chinnery, P. F.: Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission. Nat Genet 44 (11), pp. 1282 - 5 (2012)