Department Langer

Journal Article (206)

2018
Journal Article
Saita , S.; Tatsuta, T.; Lampe, P. A.; König , T.; Ohba, Y.; Langer, T.: PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria. The EMBO Journal 37 (2018)
Journal Article
Sprenger, H.-G.; Wani, G.; Hesseling, A.; Konig, T.; Patron, M.; MacVicar, T.; Ahola, S.; Wai, T.; Barth, E.; Rugarli, E. I. et al.; Bergami, M.; Langer, T.: Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med 11 (1), p. e9288 (2018)
2017
Journal Article
Tatsuta, T.; Langer, T.: Prohibitins. Curr Biol 27 (13), pp. R629 - R631 (2017)
Journal Article
Saita, S.; Nolte, H.; Fiedler, K. U.; Kashkar, H.; Venne, A. S.; Zahedi, R. P.; Kruger, M.; Langer, T.: PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis. Nat Cell Biol 19 (4), pp. 318 - 328 (2017)
Journal Article
Tatsuta, T.; Langer, T.: Intramitochondrial phospholipid trafficking. Biochim Biophys Acta 1862 (1), pp. 81 - 89 (2017)
Journal Article
Vukotic, M.; Nolte, H.; König, T.; Saita , S.; Ananjew, M.; Krüger, M.; Tatsuta, T.; Langer, T.: Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. Molecular Cell 67, pp. 471 - 483.e7 (2017)
2016
Journal Article
Wang, S.; Jacquemyn, J.; Murru, S.; Martinelli, P.; Barth, E.; Langer, T.; Niessen, C. M.; Rugarli, E. I.: The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying. PLoS Genet 12 (12), p. e1006463 (2016)
Journal Article
Wai, T.; Saita, S.; Nolte, H.; Muller, S.; Konig, T.; Richter-Dennerlein, R.; Sprenger, H.-G.; Madrenas, J.; Muhlmeister, M.; Brandt, U. et al.; Kruger, M.; Langer, T.: The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L. EMBO Rep 17 (12), pp. 1844 - 1856 (2016)
Journal Article
Koenig, T.; Troder, S. E.; Bakka, K.; Korwitz, A.; Richter-Dennerlein, R.; Lampe, P. A.; Patron, M.; Muhlmeister, M.; Guerrero-Castillo, S.; Brandt, U. et al.; Decker, T.; Lauria, I.; Paggio, A.; Rizzuto, R.; Rugarli, E. I.; De Stefani, D.; Langer, T.: The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria. Mol Cell 64 (1), pp. 148 - 162 (2016)
Journal Article
Tatsuta, T.; Langer, T.: Intramitochondrial phospholipid trafficking. Biochim Biophys Acta 1862 (1), pp. 81 - 89 (2016)
Journal Article
Hartmann, B.; Wai, T.; Hu, H.; MacVicar, T.; Musante, L.; Fischer-Zirnsak, B.; Stenzel, W.; Graf, R.; van den Heuvel, L.; Ropers, H. H. et al.; Wienker, T. F.; Hubner, C.; Langer, T.; Kaindl, A. M.: Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation. Elife 5 (2016)
Journal Article
Aaltonen, M. J.; Friedman, J. R.; Osman, C.; Salin, B.; di Rago, J. P.; Nunnari, J.; Langer, T.; Tatsuta, T.: MICOS and phospholipid transfer by Ups2-Mdm35 organize membrane lipid synthesis in mitochondria. J Cell Biol 213 (5), pp. 525 - 34 (2016)
Journal Article
Mandel, H.; Saita, S.; Edvardson, S.; Jalas, C.; Shaag, A.; Goldsher, D.; Vlodavsky, E.; Langer, T.; Elpeleg, O.: Deficiency of HTRA2/Omi is associated with infantile neurodegeneration and 3-methylglutaconic aciduria. J Med Genet 53 (10), pp. 690 - 6 (2016)
Journal Article
MacVicar, T.; Langer, T.: OPA1 processing in cell death and disease - the long and short of it. J Cell Sci 129 (12), pp. 2297 - 306 (2016)
Journal Article
Korwitz, A.; Merkwirth, C.; Richter-Dennerlein, R.; Troder, S. E.; Sprenger, H.-G.; Quiros, P. M.; Lopez-Otin, C.; Rugarli, E. I.; Langer, T.: Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol 212 (2), pp. 157 - 66 (2016)
Journal Article
Wai, T.; Garcia-Prieto, J.; Baker, M. J.; Merkwirth, C.; Benit, P.; Rustin, P.; Ruperez, F. J.; Barbas, C.; Ibanez, B.; Langer, T.: Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice. Science 350 (6265), p. aad0116 (2016)
Journal Article
Wai, T.; Langer, T.: Mitochondrial Dynamics and Metabolic Regulation. Trends Endocrinol Metab 27 (2), pp. 105 - 17 (2016)
Journal Article
Velazquez, A.; Tatsuta, T.; Ghillebert, R.; Drescher, I.; Graef, M.: Lipid droplet-mediated ER homeostasis regulates autophagy and cell survival during starvation. J Cell Biol 212 (6), pp. 621 - 31 (2016)
2015
Journal Article
Klecker, T.; Wemmer, M.; Haag, M.; Weig, A.; Bockler, S.; Langer, T.; Nunnari, J.; Westermann, B.: Interaction of MDM33 with mitochondrial inner membrane homeostasis pathways in yeast. Sci Rep 5, p. 18344 (2015)
Journal Article
Moncunill-Massaguer, C.; Saura-Esteller, J.; Perez-Perarnau, A.; Palmeri, C. M.; Nunez-Vazquez, S.; Cosialls, A. M.; Gonzalez-Girones, D. M.; Pomares, H.; Korwitz, A.; Preciado, S. et al.; Albericio, F.; Lavilla, R.; Pons, G.; Langer, T.; Iglesias-Serret, D.; Gil, J.: A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation. Oncotarget 6 (39), pp. 41750 - 65 (2015)
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