Publications of N.G. Larsson

Milenkovic, D.; Sanz-Moreno, A.; Calzada-Wack, J.; Rathkolb, B.; Veronica Amarie, O.; Gerlini, R.; Aguilar-Pimentel, A.; Misic, J.; Simard, M.-L.; Wolf, E. et al.; Fuchs, H.; Gailus-Durner, V.; de Angelis, M. H.; Larsson, N.G.: Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction. PLoS Genet 18 (5), p. e1010190 (2022)

Mennuni, M.; Filograna, R.; Felser, A.; Bonekamp, N. A.; Giavalisco, P.; Lytovchenko, O.; Larsson, N.G.: Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen. EMBO Rep 23 (1), p. e53054 (2022)

Misic, J.; Milenkovic, D.; Al-Behadili, A.; Xie, X.; Jiang, M.; Jiang, S.; Filograna, R.; Koolmeister, C.; Siira, S. J.; Jenninger, L. et al.; Filipovska, A.; Clausen, A. R.; Caporali, L.; Valentino, M. L.; La Morgia, C.; Carelli, V.; Nicholls, T. J.; Wredenberg, A.; Falkenberg, M.; Larsson, N.G.: Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion. Nucleic Acids Res 50 (15), pp. 8749 - 8766 (2022)

Bonekamp, N.; Jiang, M.; Motori, E.; Garcia Villegas, R.; Koolmeister, C.; Atanassov, I.; Mesaros, A.; Park, C. B.; Larsson, N.G.: High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo. Life Sci Alliance 4 (11), p. e202101034 (2021)

Jiang, M.; Xie, X.; Zhu, X.; Jiang, S.; Milenkovic, D.; Misic, J.; Shi, Y.; Tandukar, N.; Li, X.; Atanassov, I. et al.; Jenninger, L.; Hoberg, E.; Albarran-Gutierrez, S.; Szilagyi, Z.; Macao, B.; Siira, S. J.; Carelli, V.; Griffith, J. D.; Gustafsson, C. M.; Nicholls, T. J.; Filipovska, A.; Larsson, N.G.; Falkenberg, M.: The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication. Sci Adv 7 (27), p. eabf8631 (2021)

Sprenger, H.-G.; MacVicar, T.; Bahat, A.; Fiedler, K. U.; Hermans, S.; Ehrentraut, D.; Ried, K.; Milenkovic, D.; Bonekamp, N.; Larsson, N.G. et al.; Nolte, H.; Giavalisco, P.; Langer, T.: Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity. Nature Metabolism 3 (5), pp. 636 - 650 (2021)

Bonekamp, N.; Peter, B.; Hillen, H. S.; Felser, A.; Bergbrede, T.; Choidas, A.; Horn, M.; Unger, A.; Di Lucrezia, R.; Atanassov, I. et al.; Li, X.; Koch, U.; Menninger, S.; Boros, J.; Habenberger, P.; Giavalisco, P.; Cramer, P.; Denzel, M. S.; Nussbaumer, P.; Klebl, B.; Falkenberg, M.; Gustafsson, C. M.; Larsson, N.G.: Small-molecule inhibitors of human mitochondrial DNA transcription. Nature 588 (7839), pp. 712 - 716 (2020)

Motori, E.; Atanassov, I.; Kochan, S. M. V.; Folz-Donahue, K.; Sakthivelu, V.; Giavalisco, P.; Toni, N.; Puyal, J.; Larsson, N.G.: Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction. Sci Adv 6 (35), p. eaba8271 (2020)

Sharma, S.; Koolmeister, C.; Tran, P.; Nilsson, A. K.; Larsson, N.G.; Chabes, A.: Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos. Nat Metab 2 (8), pp. 673 - 675 (2020)

Alsina, D.; Lytovchenko, O.; Schab, A.; Atanassov, I.; Schober, F. A.; Jiang, M.; Koolmeister, C.; Wedell, A.; Taylor, R. W.; Wredenberg, A. et al.; Larsson, N.G.: FBXL4 deficiency increases mitochondrial removal by autophagy. EMBO Mol Med 12 (7), p. e11659 (2020)

Larsson, N.G.; Wedell, A.: Mitochondria in human disease. J Intern Med 287 (6), pp. 589 - 591 (2020)

Busch, J.; Cipullo, M.; Atanassov, I.; Bratic, A.; Ramos, E.S.; Schöndorf, T.; Li, X.; Pearce, S. F.; Milenkovic, D.; Rorbach, J. et al.; Larsson, N.G.: MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition. Cell Rep 29 (6), pp. 1728 - 1738 e9 (2019)

Nicholls, T. J.; Spahr, H.; Jiang, S.; Siira, S. J.; Koolmeister, C.; Sharma, S.; Kauppila, J. H. K.; Jiang, M.; Kaever, V.; Rackham, O. et al.; Chabes, A.; Falkenberg, M.; Filipovska, A.; Larsson, N.G.; Gustafsson, C. M.: Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria. Mol Cell 76 (5), pp. 784 - 796 e6 (2019)

Ramos, E.S.; Motori, E.; Bruser, C.; Kuhl, I.; Yeroslaviz, A.; Ruzzenente, B.; Kauppila, J. H. K.; Busch, J.; Hultenby, K.; Habermann, B. H. et al.; Jakobs, S.; Larsson, N.G.; Mourier, A.: Mitochondrial fusion is required for regulation of mitochondrial DNA replication. PLoS Genet 15 (6), p. e1008085 (2019)

Jiang, M.; Koolmeister, C.; Misic, J.; Siira, S.; Kuhl, I.; Silva Ramos, E.; Miranda, M.; Jiang, M.; Posse, V.; Lytovchenko, O. et al.; Atanassov, I.; Schober, F. A.; Wibom, R.; Hultenby, K.; Milenkovic, D.; Gustafsson, C. M.; Filipovska, A.; Larsson, N.G.: TEFM regulates both transcription elongation and RNA processing in mitochondria. EMBO Rep 20 (6) (2019)

Filograna, R.; Koolmeister, C.; Upadhyay, M.; Pajak, A.; Clemente, P.; Wibom, R.; Simard, M. L.; Wredenberg, A.; Freyer, C.; Stewart, J. et al.; Larsson, N.G.: Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse. Sci Adv 5 (4), p. eaav9824 (2019)

Bacman, S. R.; Kauppila, J. H. K.; Pereira, C. V.; Nissanka, N.; Miranda, M.; Pinto, M.; Williams, S. L.; Larsson, N.G.; Stewart, J.; Moraes, C. T.: Author Correction: MitoTALEN reduces mutant mtDNA load and restores tRNA(Ala) levels in a mouse model of heteroplasmic mtDNA mutation. Nat Med 24 (12), p. 1940 (2018)

Bacman, S. R.; Kauppila, J. H. K.; Pereira, C. V.; Nissanka, N.; Miranda, M.; Pinto, M.; Williams , S. L.; Larsson, N.G.; Stewart, J.; Moraes, C. T.: MitoTALEN reduces mutant mtDNA load and restores tRNA(Ala) levels in a mouse model of heteroplasmic mtDNA mutation. Nat Med 24 (11), pp. 1696 - 1700 (2018)

Kauppila, T. E. S.; Bratic, A.; Jensen, M. B.; Baggio, F.; Partridge, L.; Jasper, H.; Grönke, S.; Larsson, N.G.: Mutations of mitochondrial DNA are not major contributors to aging of fruit flies. Proc Natl Acad Sci U S A 115 (41), pp. E9620 - E9629 (2018)

Perks, K. L.; Rossetti, G.; Kuznetsova, I.; Hughes, L. A.; Ermer, J. A.; Ferreira, N.; Busch, J.; Rudler, D. L.; Spahr, H.; Schöndorf, T. et al.; Shearwood, A. J.; Viola, H. M.; Siira, S. J.; Hool, L. C.; Milenkovic, D.; Larsson, N.G.; Rackham, O.; Filipovska, A.: PTCD1 Is Required for 16S rRNA Maturation Complex Stability and Mitochondrial Ribosome Assembly. Cell Rep 23 (1), pp. 127 - 142 (2018)