Publications of M. S. Denzel

Tandon, V.; Moreno, R.; Allmeroth, K.; Quinn, J.; Wiley, S. E.; Nicely, L. G.; Denzel, M. S.; Edwards, J.; de la Vega, L.; Banerjee, S.: Dual inhibition of HSF1 and DYRK2 impedes cancer progression. Biosci Rep. 43 (1) (2023)

Wester, L. E.; Lanjuin, A.; Bruckisch , E. H.W.; Perez-Matos, M. C.; Stine, P. G.; Heintz, C.; Denzel, M. S.; Mair, W. B.: A single-copy knockin translating ribosome immunoprecipitation toolkit for tissue-specific profiling of actively translated mRNAs in C. elegans. Cell Reports Methods 3, 100433, p. 100433 (2023)

Allmeroth, K.; Hartman, M. D.; Purrio, M.; Mesaros, A.; Denzel, M. S.: Hexosamine pathway activation improves memory but does not extend lifespan in mice. Aging Cell, p. e13711 (2022)

Kroef, V.; Ruegenberg, S.; Horn, M.; Allmeroth, K.; Ebert, L.; Bozkus, S.; Miethe, S.; Elling, U.; Schermer, B.; Baumann, U. et al.; Denzel, M. S.: GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway. Elife 11 (2022)

Derisbourg, M. J.; Hartman, M. D.; Denzel, M.: Perspective: Modulating the integrated stress response to slow aging and ameliorate age-related pathology. Nat Aging 1 (9), pp. 760 - 768 (2021)

Guerrero, G. A.; Derisbourg, M. J.; Mayr, F. A. M.C.; Wester, L. E.; Giorda, M.; Dinort, J. E.; Hartman, M. D.; Schilling, K.; Alonso-De Gennaro, M. J.; Lu, R. J. et al.; Benayoun, B. A.; Denzel, M.: NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants. Elife 10, p. e53174 (2021)

Allmeroth, K.; Denzel, M.: The RATIOnal Role of Polyamines in Epidermal Differentiation. J Invest Dermatol 141 (9), pp. 2105 - 2107 (2021)

Schiffer, I.; Gerisch, B.; Kawamura, K.; Laboy, R.; Hewitt, J.; Denzel, M.; Mori, M. A.; Vanapalli, S.; Shen, Y.; Symmons, O. et al.; Antebi, A.: miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging. Elife 10 (2021)

Allmeroth, K.; Kim, C. S.; Annibal, A.; Pouikli, A.; Koester, J.; Derisbourg, M. J.; Chacón-Martínez, C. A.; Latza, C.; Annibal, A.; Tessarz, P. et al.; Wickström, S. A.; Denzel, M.: N1-acetylspermidine is a determinant of hair follicle stem cell fate. J Cell Sci 9 (134), p. jcs252767 (2021)

Ruegenberg, S.; Mayr, F. A. M.C.; Atanassov, I.; Baumann, U.; Denzel, M.: Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1. Nat Commun 12 (1), p. 2176 (2021)

Derisbourg, M. J.; Wester, L. E.; Baddi, R.; Denzel, M.: Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation. Nat Commun 12 (1), p. 1678 (2021)

Bonekamp, N.; Peter, B.; Hillen, H. S.; Felser, A.; Bergbrede, T.; Choidas, A.; Horn, M.; Unger, A.; Di Lucrezia, R.; Atanassov, I. et al.; Li, X.; Koch, U.; Menninger, S.; Boros, J.; Habenberger, P.; Giavalisco, P.; Cramer, P.; Denzel, M. S.; Nussbaumer, P.; Klebl, B.; Falkenberg, M.; Gustafsson, C. M.; Larsson, N.G.: Small-molecule inhibitors of human mitochondrial DNA transcription. Nature 588 (7839), pp. 712 - 716 (2020)

Kim, C. S.; Ding, X.; Allmeroth, K.; Biggs, L. C.; Kolenc, O. I.; L'Hoest, N.; Chacón-Martínez, C. A.; Edlich-Muth, C.; Giavalisco, P.; Quinn, K. P. et al.; Denzel, M. S.; Eming, S. A.; Wickström, S. A.: Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle. Cell Metab 32 (4), pp. 629 - 642 e8 (2020)

Allmeroth, K.; Horn, M.; Kroef, V.; Miethe, S.; Muller, R. U.; Denzel, M. S.: Bortezomib resistance mutations in PSMB5 determine response to second-generation proteasome inhibitors in multiple myeloma. Leukemia 35 (3), pp. 887 - 892 (2020)

Horn, M.; Denzel, S. I.; Srinivasan, B.; Allmeroth, K.; Schiffer, I.; Karthikaisamy, V.; Miethe, S.; Breuer, P.; Antebi, A.; Denzel, M. S.: Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response. iScience 23 (3), p. 100887 (2020)

Ruegenberg, S.; Horn, M.; Pichlo, C.; Allmeroth, K.; Baumann, U.; Denzel, M. S.: Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun 11 (1), p. 687 (2020)

Saez, I.; Gerbracht, J. V.; Koyuncu, S.; Lee, H. J.; Horn, M.; Kroef, V.; Denzel, M. S.; Dieterich, C.; Gehring, N. H.; Vilchez, D.: The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells. FEBS Lett 594 (1), pp. 175 - 188 (2019)

Horn, M.; Metge, F.; Denzel, M. S.: Unbiased Forward Genetic Screening with Chemical Mutagenesis to Uncover Drug-Target Interactions. Methods Mol Biol 1953, pp. 23 - 31 (2019)

Sawarkar, R.; Scherz-Shouval, R.; Denzel, M. S.; Saarikangas, J.: Chaperoning junior faculty: Institutional support and guidance can relieve challenges for early-career group leaders and improve academic performance. EMBO Rep 20 (1) (2018)

Denzel, M. S.; Lapierre, L. R.; Mack, H. I. D.: Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics. Mech Ageing Dev 177, pp. 4 - 21 (2018)